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Fig. 6 | BMC Bioinformatics

Fig. 6

From: Analysis of in vivo single cell behavior by high throughput, human-in-the-loop segmentation of three-dimensional images

Fig. 6

Relationship between Nanog and Cdx2 contents in preimplantation mouse embryos. a-c Mouse embryo stained for DNA (a) Cdx2 (b) and Nanog (c; white arrows point to the same two cells in each panel). d Control embryos cultured for 12 h (28.5 ± 6.8 cells per embryo, n = 8) show a positive relationship between Nanog and Cdx2 (interior linear fit slope 0.13, 95 % CI = [0.08, 0.18]; periphery linear fit slope 0.11, 95 % CI = [0.05, 0.17]). e Embryos cultured for 24 h with BMP signaling inhibitor LDN (29.4 ± 10.2 cells per embryo, n = 12) do not show a positive relationship between Nanog and Cdx2 content (interior linear fit slope 0.07, 95 % CI = [0.03, 0.10]; periphery linear fit slope 0.01, 95 % CI = [−0.03, 0.05])

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BMC Bioinformatics

ISSN: 1471-2105

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