TY - JOUR AU - Li, Gengxin AU - Zhao, Hongyu PY - 2015 DA - 2015/12/03 TI - M3-S: a genotype calling method incorporating information from samples with known genotypes JO - BMC Bioinformatics SP - 403 VL - 16 IS - 1 AB - A key challenge in analyzing high throughput Single Nucleotide Polymorphism (SNP) arrays is the accurate inference of genotypes for SNPs with low minor allele frequencies. A number of calling algorithms have been developed to infer genotypes for common SNPs, but they are limited in their performance in calling rare SNPs. The existing algorithms can be broadly classified into three categories, including: population-based methods, SNP-based methods, and a hybrid of the two approaches. Despite the relatively better performance of the hybrid approach, it is still challenging to analyze rare SNPs. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-015-0824-5 DO - 10.1186/s12859-015-0824-5 ID - Li2015 ER -