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Fig. 4 | BMC Bioinformatics

Fig. 4

From: MixChIP: a probabilistic method for cell type specific protein-DNA binding analysis

Fig. 4

Estimating cell type specific binding affinity and input control signal improves TF binding predictions in the cell types of the interest when compared to the traditional approach where sample heterogeneity is not corrected for. ROC curve of JUND binding predictions for MixChIP (black curve) and combining p-values of individual samples by taking the maximum of p-values (orange curve) in (a) HepG2 and (b) K562 cell lines. c Estimated proportions (grey dots) of HepG2 cells when true proportions are used as an informative prior (orange dots). df ROCs and the estimated proportions as in (a-c) when priors are intentionally set to differ from the true proportions

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