Table 3 Validation of the predicted signaling components against recent literature and KEGG database

Notch

{RFNG}

{DTX4,RFNG,KAT2A,DTX2,DTX3L}

{RNF2,RING1B} [38]; {TBL1XR1} [39];{POGLUT1} [40]

TCR

{CD8B,PAK2}

{PAK7,PAK2,IFNG,PAK4,AKT3}

{SNX27} [41]

TGFBeta

{SMAD5,CDKN2B,PITX2}

{GDF5,AMHR2,BMP5,PPP2CB,GDF7,ACVR1B,PITX2,INHBA,BMPR2,SMAD5,GDF6,ACVR2A,ACVR2B,INHBB,BMPR1A,ACVR1,BMP7,BMPR1B}

{RBPMS} [42]; {BMP15} [43]

TNF

{BAG4,RPS6KA4}

{CREB3L3,LTA}

{TNFAIP8} [44]

Wnt

{WNT16,WNT8A,WNT2B,DKK4,CSNK1A1L,WNT8B,GPC4,CXXC4,SFRP5,CTNNBIP1,NKD2,PORCN,TCF7L1,NKD1,SOX17,CSNK2A2,WNT10B,DKK2,APC2,TCF7,WNT10A}

{WNT16,PPARD,WNT8A,WNT2B,DKK4,WNT8B,CSNK1A1L,GPC4,CXXC4,PPP3CC,SFRP5,CTNNBIP1,PORCN,TCF7L1,CSNK2A2,WNT10B,DKK2,APC2,TCF7,WNT10A}

{WNT9A,SOX13} [45];

BCR

{AKT3,LILRB3}

{MAP3K12} [46]

Hedgehog

{ZIC2}

{MED12} [47]

Prolactin

{AKT3}

{PIK3C3} [46]