Table 4 Validation of the predicted signaling components against Reactome database and Signalink database

Notch

{HDAC9,POGLUT1,HEYL,TLE2,TBL1XR1,TLE4,TLE1,HEY1,TLE3,B4GALT1,DLK1,CCNC,HDAC3,RFNG,HDAC10}

{TBL1XR1,HDAC4,DTX4,RFNG,POGLUT1,HEYL,HDAC9,KAT2A,HDAC8,DTX2,HEY1,DLK1,MIB2,HDAC10,HDAC3}

TCR

{MRC1,KLC1,TUBA1C,PAK2,TUBB3,KLRK1,KLRG1,CD8B,TUBA4A,TUBB4A,TUBB4B,TUBB2B,PDGFRA,DCTN2,TUBA1B,CD226,LILRB2,ITGAL,TUBB2A,TUBB6,KIF15,TUBB1,KIF5A,LILRB3}

{RNF138,PAK2,TUBB3,ERAP1,CD274,OSBPL1A,KIR2DL1,AGO3,TUBA1B,AKT3,TUBB6,TUBB2A,TUBA3C,ANAPC11,RNF41,TUBA1C,KIR3DL1,DNM3,TUBA4A,SPTBN2,PHLPP1,TUBB4B,TUBB4A,TUBB2B,TRIM21,CXADR,RNF123,TRIM9,PVRL2,TRIM11,TUBB1,PHLPP2}

-

TGFBeta

{MEN1,UBB,TGIF2,CDKN2B}

{UBE2M,TGIF2,RPS27A,MTMR4}

Wnt

{TNKS2,WNT16,WNT8A,PYGO2,WNT2B,DKK4,WNT8B,CXXC4,RSPO4,AMER1,CTNNBIP1,PORCN,RNF43,TCF7L1,KREMEN2,SOX17,DACT1,CSNK2A2,WLS,WNT10B,DKK2,CCDC88C,TCF7,PYGO1,WNT10A}

{WNT16,PPP2CB,WNT8A,WNT2B,WNT8B,AMER1,CTNNBIP1,DACT1,CSNK2A2,SOX13,PYGO2,DKK4,CXXC4,PORCN,TCF7L1,KREMEN2,SOX6,BCL9L,WLS,WNT10B,DKK2,TCF7,WNT10A}

{WNT8A,APC2}

BCR

{ITPR3}

{AKT3,ITPR3}

-

EGFR

{AGO4,AP2A2,MLST8,FGF3,AGO3,AKT3,RPS27A}

{AP2A2,PDGFRA,AKT3,ADAM12,PDGFB,PHLPP2}

-