Table 4 The common paths using DAVID and CPDB for late-stage NSCLC (the p _M -value and p _T -value represent the corresponding p-value obtained by machine learning algorithms and topological parameter-based classification)

pathname

p _M -value

p _T -value

pathname

p _M -value

p _T -value

Cell cycle

0.03800

0.00140

Cell Cycle Checkpoints

0.00760

0.00872

Cell Cycle, Mitotic

0.00100

0.02186

pathname

p _M -value

p _T -value

pathname

p _M -value

p _T -value

Cell cycle

0.00632

0.00004

Regulation of mitotic cell cycle

0.01500

0.00000

Inflammatory mediator regulation of TRP channels

0.03960

0.00048

APC/C:Cdc20 mediated degradation of mitotic proteins

0.01500

0.00000

Endocytosis

0.00051

0.00153

Activation of APC/C and APC/C: Cdc20 mediated degradation of mitotic proteins

0.00663

0.00001

Thyroid hormone synthesis

0.01560

0.00662

Cell Cycle Checkpoints

0.00729

0.00001

Salivary secretion

0.03120

0.01370

Cell Cycle

0.00007

0.00001

Long-term depression

0.04420

0.02330

Regulation of APC/C activators between G1/S and early anaphase

0.00177

0.00001

cGMP-PKG signaling pathway

0.02210

0.02740

G1/S Transition

0.01030

0.00002

Vascular smooth muscle contraction

0.00497

0.03440

Cdc20:Phospho-APC/C mediated degradation of Cyclin A

0.00837

0.00004

Cell Cycle, Mitotic

0.00485

0.00014

APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfaction of the cell cycle checkpoint

0.00182

0.00014

Mitotic G1-G1/S phases

0.00541

0.00016

G2/M Checkpoints

0.02590

0.00023

M Phase

0.00298

0.00119

DNA Replication

0.00813

0.00153

Resolution of Sister Chromatid Cohesion

0.00103

0.00297

Mitotic Prometaphase

0.00230

0.00399

Apoptotic cleavage of cellular proteins

0.00067

0.00572

S Phase

0.01500

0.00762

Mitotic Anaphase

0.02040

0.00875

Mitotic Metaphase and Anaphase

0.00035

0.01140

Apoptotic execution phase

0.00036

0.01170

Synthesis of DNA

0.03370

0.01760

Separation of Sister Chromatids

0.00540

0.01760