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Table 4 The common paths using DAVID and CPDB for late-stage NSCLC (the p M -value and p T -value represent the corresponding p-value obtained by machine learning algorithms and topological parameter-based classification)

From: Drug repositioning for non-small cell lung cancer by using machine learning algorithms and topological graph theory

DAVID
KEGG REACTOME
pathname p M -value p T -value pathname p M -value p T -value
Cell cycle 0.03800 0.00140 Cell Cycle Checkpoints 0.00760 0.00872
    Cell Cycle, Mitotic 0.00100 0.02186
CPDB
KEGG REACTOME
pathname p M -value p T -value pathname p M -value p T -value
Cell cycle 0.00632 0.00004 Regulation of mitotic cell cycle 0.01500 0.00000
Inflammatory mediator regulation of TRP channels 0.03960 0.00048 APC/C:Cdc20 mediated degradation of mitotic proteins 0.01500 0.00000
Endocytosis 0.00051 0.00153 Activation of APC/C and APC/C: Cdc20 mediated degradation of mitotic proteins 0.00663 0.00001
Thyroid hormone synthesis 0.01560 0.00662 Cell Cycle Checkpoints 0.00729 0.00001
Salivary secretion 0.03120 0.01370 Cell Cycle 0.00007 0.00001
Long-term depression 0.04420 0.02330 Regulation of APC/C activators between G1/S and early anaphase 0.00177 0.00001
cGMP-PKG signaling pathway 0.02210 0.02740 G1/S Transition 0.01030 0.00002
Vascular smooth muscle contraction 0.00497 0.03440 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.00837 0.00004
    Cell Cycle, Mitotic 0.00485 0.00014
    APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfaction of the cell cycle checkpoint 0.00182 0.00014
    Mitotic G1-G1/S phases 0.00541 0.00016
    G2/M Checkpoints 0.02590 0.00023
    M Phase 0.00298 0.00119
    DNA Replication 0.00813 0.00153
    Resolution of Sister Chromatid Cohesion 0.00103 0.00297
    Mitotic Prometaphase 0.00230 0.00399
    Apoptotic cleavage of cellular proteins 0.00067 0.00572
    S Phase 0.01500 0.00762
    Mitotic Anaphase 0.02040 0.00875
    Mitotic Metaphase and Anaphase 0.00035 0.01140
    Apoptotic execution phase 0.00036 0.01170
    Synthesis of DNA 0.03370 0.01760
    Separation of Sister Chromatids 0.00540 0.01760