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Table 1 Gene Ontology categories enriched by differentially expressed genes among TB, LTBI, and healthy control (HC)

From: Gene expression profiling identifies candidate biomarkers for active and latent tuberculosis

TB vs. HC

LTBI vs. HC

LTBI vs. TB

1. Immune response

Regulation of metabolic process

Response to cold

2. Leukocyte differentiation

Regulation of cellular Metabolic process

Immune Response-regulating signaling pathway

3. Immune system process

Regulation of biosynthetic process

Cellular process

4. B cell activation

Apoptotic process

Immune response- activating signal transduction

5. Lymphocyte differentiation

Death

Heterotypic cell-cell adhesion

6. Regulation of immune response

Regulation of gene expression

NK T cell differentiation

7. Positive regulation of response to stimulus

MAP kinase phosphatase activity

Regulation of mRNA catabolic process

8. Lymphocyte activation

Translation factor activity,

Translation regulator activity

9. Leukocyte activation

Translation initiation factor activity

NF-kappaB binding

10. Chemokine receptor activity

Protein tyrosine/threonine phosphatase activity

Translation repressor activity

  1. WebGestalt setting: multiple test adjustment = Benjamini-Hochberg, significance level = top 10 (Benjamini-Hochberg adjusted p < 0.05); minimum number of genes for a category = 2