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Table 2 FNA performance per cytology group

From: The diagnostic application of RNA sequencing in patients with thyroid cancer: an analysis of 851 variants and 133 fusions in 524 genes

Performance on Cytology Benign (n = 30)
Genetic alteration Histology malignant (n = 6) Histology benign (n = 24)
Positive 0 4
Negative 6 20
  1. Sensitivity, 0 % (0–46); Specificity, 83 % (63–95); PPV, 16 % (5–50); NPV, 79 % (73–85), prevalence of malignant lesions, 20 %. Estimated performance when malignancy is prevalent at 6 %: PPV, 5 % (1–20); NPV, 94 % (91–96)