Fig. 1
From: BigQ: a NoSQL based framework to handle genomic variants in i2b2
System components and their interrelationships. BigQ-ETL requires the user to provide one or more VCF files that are functionally annotated with ANNOVAR and used to create one JSON document for each variant belonging to each patient; these JSONs are stored in CouchDB to be queried by the BiqQ-Cell. On the client-side, the BigQ-plugin allows the user to create a genetic query with drag-and-drop interactions within the i2b2 Webclient; the plugin then communicates with the cell to run the query and collect the results that are shown to the user