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Fig. 2 | BMC Bioinformatics

Fig. 2

From: ChainRank, a chain prioritisation method for contextualisation of biological networks

Fig. 2

Changes in the representation of IGF-Akt pathway. a shows the protein synthesis regulation related part of IGF-Akt pathway [21]. In this pathway representation relations of proteins are well annotated with their directionality, type of interaction, etc. b shows that during manual conversion of the canonical pathways to PPI network representation (by retrieving all PPI interactions between the fixed set of e nodes) this kind of information is lost and only undirected edges represent physical binding between proteins. Moreover, the structure of the pathway is altered by extra edges and some connections are missing. c shows the effect of the network selection which removes redundant edges but retains most of the nodes

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