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Table 1 Mendelian error rate (Simulation II). The mean number of Mendelian errors for each offspring with sequencing coverage of 5x, 10x. 20x and 30x from our proposed method “FamLDCaller” (FLDC) compared with the results from Genome Analysis Toolkit (GATK). (F3: trios; F4: nuclear families of two offspring; F5: nuclear families with three offspring and F6: complex families with three generations.)

From: A computational method for genotype calling in family-based sequencing data

Depth

5

10

20

30

Method

GATK

FLDC

GATK

FLDC

GATK

FLDC

GATK

FLDC

F3

28,213

1118

6475

483

927

182

628

164

F4

28,213

962

6475

350

927

135

628

126

F5

28,213

718

6475

228

927

94

628

86

F6

33,427

351

7420

99

1161

46

805

39