A two-phase procedure for non-normal quantitative trait genetic association study

BMC Bioinformatics

Table 4 The p-values of 17 SNPs in gene DNAH9 for the association with Anti-CCP Measure

snpid	KW	Z _A	MAX3	TPP	Genetic model	α ^∗
rs9896319	0.0024	0.0542	0.0060	0.0031	REC	3.16×10⁻⁵
rs736626	0.1008	0.0337	0.0720	0.0337	ADD	2.98×10⁻⁵
rs4791473	0.0621	0.0214	0.0436	0.0214	ADD	2.99×10⁻⁵
rs12946617	0.1182	0.0459	0.0962	0.0459	ADD	3.75×10⁻⁵
rs7223160	0.0894	0.0289	0.0624	0.0289	ADD	2.98×10⁻⁵
rs7207282	0.1039	0.0345	0.0738	0.0345	ADD	2.98×10⁻⁵
rs11657375	0.1359	0.0412	0.0880	0.0412	ADD	3.29×10⁻⁵
rs11651010	0.0002	0.0001	0.0001	0.0001	ADD	3.03×10⁻⁵
rs3744580	0.0804	0.0390	0.0561	0.0390	ADD	2.99×10⁻⁵
rs11655963	1.18×10⁻⁴	8.40×10⁻⁵	7.44×10⁻⁵	2.72×10⁻⁵	REC	3.64×10⁻⁵
rs12936861	0.0529	0.0594	0.0336	0.0146	DOM	2.87×10⁻⁵
rs9896309	0.0356	0.1863	0.0446	0.0205	DOM	2.86×10⁻⁵
rs7215021	0.1275	0.0384	0.0715	0.0384	ADD	3.48×10⁻⁵
rs9303041	0.0507	0.1855	0.0327	0.0149	DOM	3.16×10⁻⁵
rs10445247	0.0481	0.0320	0.0491	0.0320	ADD	2.92×10⁻⁵
rs3764845	0.0719	0.0325	0.0698	0.0325	ADD	2.91×10⁻⁵
rs1990236	0.0622	0.0217	0.0365	0.0217	ADD	3.27×10⁻⁵

α ^∗ is the adjusted p-value threshold for 5×10⁻⁵. The sixth column (denoted by Genetic model) is the selected genetic model using the TPP in the first phase

ISSN: 1471-2105