Table 5 Top five predicted interactions by KRONRLS-MKL
From: A multiple kernel learning algorithm for drug-target interaction prediction
Drug | Target | |||
|---|---|---|---|---|
Nuclear Receptors | ||||
D00951 | Medroxyprogesterone acetate | hsa2099 | estrogen receptor 1 | (D,C) |
D00585 | Mifepristone | hsa2099 | estrogen receptor 1 | (C) |
D00182 | Norethisterone | hsa2099 | estrogen receptor 1 | (C) |
D00105 | Estradiol | hsa5241 | progesterone receptor | (C) |
D00094 | Tretinoin | hsa6095 | RAR-related orphan receptor A | |
GPCR | ||||
D02358 | Metoprolol | hsa154 | adrenoceptor beta 2, surface | (D,C) |
D00283 | Clozapine | hsa1814 | dopamine receptor D3 | (D,C,M) |
D00371 | Theophylline | hsa135 | adenosine A2a receptor | (K,D,C) |
D00371 | Theophylline | hsa134 | adenosine A1 receptor | (K,D,C) |
D00095 | Adrenaline | hsa155 | adrenoceptor beta 3 | (K,D,C) |
Ion Channel | ||||
D00775 | Riluzole | hsa2898 | glutamate receptor, ionotropic, kainate 2 | (M) |
D02356 | Verapamil | hsa6833 | ATP-binding cassette, sub-family C (CFTR | |
D00294 | Diazoxide | hsa10060 | ATP-binding cassette, sub-family C (CFTR | |
D02356 | Verapamil | hsa56660 | potassium channel, two pore domain subfamily K, member 12 | |
D00524 | Carbachol | hsa1134 | cholinergic receptor, nicotinic, alpha 1 (muscle) | |
Enzyme | ||||
D00542 | Halothane | hsa1571 | cytochrome P450, family 2, subfamily E, polypeptide 1 | (D,C,M) |
D00437 | Nifedipine | hsa1559 | cytochrome P450, family 2, subfamily C, polypeptide 9 | (D,C,M) |
D00528 | Anhydrous caffeine | hsa1549 | cytochrome P450, family 2, subfamily A, polypeptide 7 | (M) |
D03670 | Deferoxamine | hsa1579 | cytochrome P450, family 4, subfamily A, polypeptide 11 | |
D00139 | Methoxsalen | hsa1543 | cytochrome P450, family 1, subfamily A, polypeptide 1 | (D,M) |