Fig. 1
From: Intra- and interspecies gene expression models for predicting drug response in canine osteosarcoma
The Co-expression Extrapolation (COXEN) method. Steps 1–3 involve identifying a gene signature that predicts chemosensitivity from the reference set. Steps 4–5 involve gene expression data from the co-expression set and identifying a subset of the gene signature that shares strong co-expression with the co-expression set. The resulting genes are candidates in prediction model development in step 6, and the resulting predictions are compared to actual chemosensitivity or clinical outcome in step 7