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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Intra- and interspecies gene expression models for predicting drug response in canine osteosarcoma

Fig. 2

The effect of in vitro human COXEN models on predicting canine cell line sensitivity to doxorubicin or carboplatin. a GI50 ranges of the human NCI60 panel to 3 chemotherapeutics commonly used for canine osteosarcoma treatment were compared to the GI50 ranges generated in the canine FACC panel via Alamar Blue assays. b Differentially expressed genes based on sensitivity of NCI60 samples to doxorubicin were used in the most and least sensitive NCI60 and FACC samples in unsupervised hierarchical clustering. Light green and pink bars refer to sensitive and resistant samples, respectively. Blue and yellow bars refer to NCI60 and FACC samples, respectively. c & d COXEN predictions of doxorubicin (c) or carboplatin (d) sensitivity in the FACC cells from NCI60-trained models compared to actual GI50 values. Significance of accurate predictions determined by binomial test. ER = Error Rate

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