Fig. 3
From: Intra- and interspecies gene expression models for predicting drug response in canine osteosarcoma
Cell line-trained models on clinical outcome in canine osteosarcoma patients treated with doxorubicin and/or carboplatin. a & b Analysis comparing the survival curves of COS33 patients predicted to respond or not respond to doxorubicin (n = 22) (a) or carboplatin (n = 25) (b) from a NCI60-trained model with the COS16 tumor panel used as the co-expression set. c Survival analysis of predicted responders and non-responders in the COS33 to doxorubicin from a model trained on the osteosarcoma cell line subset of the FACC panel, with the COS16 used for co-expression. d Survival analysis of predicted responders and non-responders in the COS33 to carboplatin from a FACC-trained model co-expressed with the COS16. Significant difference in disease free interval between predicted groups was determined by Log Rank test