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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL)

Fig. 2

Conceptual illustration of the IDOL algorithm. a Schematic diagram showing each step of IDOL. b, c Illustration of the scheme for updating the selection probabilities of L-DMRs. d Conceptual depiction of the L-DMR selection probabilities as a function of the sequential progression of IDOL. At iteration 0, L-DMRs have an equal probability of being selected for inclusion in the randomly assembled L-DMR subset. At each sequential iteration of IDOL (i.e., moving from left to right), the selection probabilities for L-DMRs are updated in a manner proportion to their contribution to prediction performance; selection probabilities for L-DMRs that contribute favorably to prediction performance are increased (increasing shades of green), whereas the selection probabilities for those that hinder prediction performance are decreased (increasing shades of red). Upon algorithm termination, the J L-DMRs with the largest selection probabilities are taken to represent the optimal L-DMR library. e, f Plots showing mean RMSE (\(\bar {M}\)) and coefficient of determination (\(\bar {R}^{2}\)) respectively, as a function of sequential progression of the the IDOL algorithm

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