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Fig. 5 | BMC Bioinformatics

Fig. 5

From: Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL)

Fig. 5

Cell mixture deconvolution of the Liu and Hannum blood data sets using the IDOL and EstimateCellCounts libraries. a, b Scatter plots of the predicted cell type fractions obtained using EstimateCellCounts library (x-axes) and the IDOL library (y-axes) for the Liu and the Hannum data sets, respectively. c, d Distribution of the difference in the R 2 computed from the IDOL and EstimateCellCounts libraries for the (c) Liu and (d) Hannum data sets. e, f Estimated number of additional samples needed (y-axis, left) and approximate additional cost (y-axis, right) as a function of the desired difference in DNA methylation to be detected (x-axis) when correction for cell mixture was carried out using the EstimateCellCounts library. Variance estimates were obtained from the (e) Liu and (d) Hannum data sets

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