Fig. 1

Overview of D³E. a Graphical representation of the transcriptional bursting model. b Example of a realization of the transcriptional bursting model with parameters α=1,β=10, γ=100, and λ=1 [12]. In this regime, the gene exhibits a bursty behavior with a bimodal stationary distribution. c Derivation of the biologically-relevant parameters from the parameters of the transcriptional bursting model. d Flowchart of the D³E algorithm