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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Structure-based Markov random field model for representing evolutionary constraints on functional sites

Fig. 2

Association of pairwise coevolution scores and functional sites. a For the CSA data set, the fraction of residue pairs with at least one catalytic site among hits is represented across the rank cutoff. b For the ASD data set, the fraction of residue pairs with at least one allosteric site among hits is represented across the rank cutoff. In (a) and (b), the rank is normalized by the sequence length of the target protein. For example, the normalized ranks 0.1, 0.2, and 0.5 are equivalent to the top-L/10, top-L/5, and top-L/2, where L is the sequence length of the target protein. The gray shadow represents the standard deviation

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