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Table 5 The Gene Ontology results of the subnetwork identified by RLRNPI-AEN for dataset GSE11121

From: Regularized logistic regression with network-based pairwise interaction for biomarker identification in breast cancer

Subnetwork GO number Ontology description Adjusted p-value
AGER ATP2A3 CRK CSF2RA DLGAP2 ECT2 F2RL2 FYN GRB2 MAP2K5 NCK1 PIK3R1 SEMA7A TPSAB1 TPSB2 WIPF2 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 2.66×10−10
  GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 2.66×10−10
  GO:0038094 Fc-gamma receptor signaling pathway 2.66×10−10
  GO:0002431 Fc receptor mediated stimulatory signaling pathway 2.70×10−10
  GO:0006909 phagocytosis 5.53×10−8
CREB3 MS4A1 ICAM4 FA2H GO:0031726 CCR1 chemokine receptor binding 2.25×10−2
  GO:0008140 cAMP response element binding protein binding 2.25×10−2
  GO:0044877 macromolecular complex binding 2.25×10−2
  GO:0035497 cAMP response element binding 2.76×10−2
  GO:0005102 receptor binding 2.76×10−2
AGGF1 CCDC85B PRC1 NGFRAP1 GO:0005123 death receptor binding 4.17×10−2
  GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 4.17×10−2
  GO:0016505 peptidase activator activity involved in apoptotic process 4.17×10−2
  GO:0019894 kinesin binding 4.17×10−2
  GO:0016504 peptidase activator activity 4.17×10−2
  1. The first column (Subnetwork) presents the elements of subnetwork of which the functional and biological relationship are analyzed based on the GO annotation