Table 3 GO and pathway enrichment of predicted meta modules
From: A NMF based approach for integrating multiple data sources to predict HIV-1–human PPIs
Sl. No | No of genes | GO terms | KEGG pathway |
|---|---|---|---|
1 | 219 | translational elongation (1.5e-15) | Ribosome (6.7e-16) |
2 | 35 | positive regulation of transcription, DNA-dependent (2.8e-2) | not found |
3 | 248 | RNA processing (7.0E-8) | Ribosome (3.6e-4) |
4 | 29 | positive regulation of protein metabolic process (1.1e-3) | Proteasome (6.1e-3) |
5 | 205 | translational elongation (1.3E-28) | Ribosome (3.8E-21) |
6 | 32 | protein kinase cascade (5.1E-3) | Notch signaling pathway (9.7E-2) |
7 | 31 | regulation of actin filament polymerization (5.5E-3) | Cell cycle (5.7E-2) |
8 | 138 | regulation of programmed cell death (1.5E-5) | Natural killer cell mediated cytotoxicity (5.1E-4) |
9 | 133 | immune response (5.2E-8) | Allograft rejection (1.1E-5) |
10 | 106 | cell cycle (7.4E-6) | DNA replication (2.8E-4) |
11 | 92 | translational elongation (1.3E-21) | Ribosome (1.1E-19) |
12 | 89 | translational elongation (2.4E-15) | Ribosome (2.1E-13) |
13 | 80 | RNA splicing (3.1E-13) | Spliceosome (3.1E-5) |
14 | 82 | immune response (3.2E-3) | Regulation of actin cytoskeleton (4.9E-3) |
15 | 69 | chromatin modification (1.8E-2) | Cell cycle (2.2E-2) |
16 | 41 | regulation of cellular protein metabolic process (1.8E-4) | Huntington’s disease (2.1E-2) |
17 | 76 | electron transport chain (8.9E-5) | Parkinson’s disease (4.5E-9) |
18 | 68 | regulation of apoptotic process (2.7E-5) | T cell receptor signaling pathway (1.2E-2) |
19 | 66 | DNA metabolic process (1.9E-3) | Cell cycle (9.3E-2) |
20 | 40 | negative regulation of molecular function (1.9E-4) | not found |
21 | 72 | regulation of organelle organization (2.2E-3) | Fc gamma R-mediated phagocytosis (1.6E-2) |
22 | 64 | RNA splicing (2.9E-10) | Spliceosome (3.9E-9) |
23 | 62 | muscarinic acetylcholine receptor signaling pathway (7.5E-4) | Chemokine signaling pathway (1.4E-2) |
24 | 42 | RNA processing (7.5E-3) | Spliceosome (2.9E-2) |
25 | 68 | purine ribonucleoside monophosphate biosynthetic process (1.8E-3) | Ribosome (5.9E-3) |
26 | 24 | immune response (3.6E-4) | Aminoacyl-tRNA biosynthesis (7.8E-2) |
27 | 59 | regulation of DNA binding (4.0E-3) | Systemic lupus erythematosus (9.6E-3) |
28 | 27 | cellular defense response (5.6E-3) | Endocytosis (5.3E-2) |
29 | 183 | oxidative phosphorylation (7.9E-5) | Parkinson’s disease (6.9E-4) |
30 | 19 | negative regulation of macromolecule metabolic process (5.3E-2) | not found |