Fig. 4

isomiRs percentages. Subfigures (a), (b), (c), (d), (e) and (f) show respectively for human miR-181a-3p, miR-154-3p, miR-29a-3p, miR-664a-5p, miR-34c-5p and let-7e-5p, the isomiRs percentages detected in the samples on x-axis. In particular the left y-axis reports on the percentages of isomiRs, whereas the right y-axis on the absolute reads counts. In each Subfigure the first 14 bars are relative to human samples, whereas the last 14 to the macaque ones. Moreover the development and ageing stages are divided by a dark-grey bar. The different samples are labelled with a unique identifier in the format speciesnumsample-age: The character h and m identify respectively human or macaque samples, numsample ranges from 01–14 for both the species and the age is in the form of years. The bold line, that separates in two groups the analysed samples in both the species, represents the transition age that divides the developmental from the ageing stages. IsomiRs are depicted with different colors according to the legend of Fig. 5. The black trend curve reports on isomiR-SEA reads counts