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Table 3 Penetrance table for model Interaction only, β I =0.4, M A F I =0.4. A 1 and B 1 represent the major alleles and A 2 and B 2 the minor alleles

From: Do little interactions get lost in dark random forests?

   SNP 1
   A 1 A 1 A 1 A 2 A 2 A 2
  B 1 B 1 0.35 0.35 0.35
SNP 2 B 1 B 2 0.35 0.44 0.54
  B 2 B 2 0.35 0.54 0.72
  1. Compared with Table 1 it can be seen that a variant at both SNPs is required for a penetrance larger than the baseline of 0.35. Since the phenotype is simulated with an additive model, the penetrance is increased if two minor alleles are present at one SNP. The penetrances for other models and parameters are computed analogously and are shown in Tables S1–S20 (Additional file 2)
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