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Table 2 The semantics and statistics of commuting matrixes

From: Predicting drug target interactions using meta-path-based semantic network analysis

Index Semantics Counta Maxb
C1 \( \mathrm{compound}\ \overset{similar\;to}{\to}\;\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein} \) 1995778 395
C2 \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{interacts\; with}{\to}\mathrm{protein} \) 4878633 20
C3 \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{similar\ to}{\to}\mathrm{protein} \) 30665527 84
C4 \( \mathrm{compound}\ \overset{treats}{\to}\;\mathrm{disease}\overset{caused\;by}{\to}\mathrm{protein} \) 6178 3
C5 \( \mathrm{compound}\ \overset{similar\;to}{\to}\;\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein} \) 15086309 934
C6 \( \mathrm{compound}\ \overset{similar\;to}{\to}\;\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\ to}{\to}\mathrm{protein} \) 49226573 1163
C7 \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{binds\;to}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein} \) 126339670 30400
C8 \( \mathrm{compound}\ \overset{has\; part}{\to}\;\mathrm{substructure}\overset{part\; of}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein} \) 922056 202
C9 \( \mathrm{compound}\ \overset{has\; type}{\to}\;\mathrm{ChEBI}\ \mathrm{type}\overset{type\ of}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein} \) 709802 324
C10 \( \mathrm{compound}\ \overset{induces}{\to}\;\mathrm{adverse}\ \mathrm{side}\ \mathrm{effect}\overset{induced\kern0.5em by}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein} \) 420616 194
C11 \( \mathrm{compound}\ \overset{treats}{\to}\;\mathrm{disease}\overset{treated\;by}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein} \) 68479 25
C12 \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{has\; annotation}{\to}\mathrm{GO}\ \mathrm{annotation}\overset{annotation\ of}{\to}\mathrm{protein} \) 316095950 335
C13 \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{participates\; in}{\to}\mathrm{pathway}\overset{has\ participants}{\to}\mathrm{protein} \) 82834409 328
C14 \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{expressed\; in}{\to}\mathrm{tissue}\overset{expresses}{\to}\mathrm{protein} \) 53586080 76
C15 \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{causes}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) 1360337 10
C16 \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{binds\;to}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein}\overset{interact\ with}{\to}\mathrm{protein} \) 522513250 142290
C17 \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{binds\;to}{\to}\mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) 12963831 498
C18 \( \mathrm{compound}\ \overset{binds\;to}{\to}\mathrm{protein}\ \overset{binds\;to}{\to}\mathrm{compound}\ \overset{similar\;to}{\to}\mathrm{compound}\ \overset{binds\;to}{\to}\mathrm{protein} \) 201052081 777576
C19 \( \mathrm{compound}\ \overset{binds\;to}{\to}\mathrm{protein}\ \overset{binds\;to}{\to}\mathrm{compound}\ \overset{binds\;to}{\to}\mathrm{protein}\ \overset{similar\;to}{\to}\mathrm{protein} \) 356122463 445332
C20 \( \mathrm{compound}\ \overset{type\; of}{\to}\mathrm{ChEBI}\ \mathrm{type}\ \overset{type\; of}{\to}\mathrm{compound}\ \overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein} \) 2333739 2711
C21 \( \mathrm{compound}\ \overset{type\; of}{\to}\mathrm{ChEBI}\ \mathrm{type}\ \overset{type\; of}{\to}\mathrm{compound}\overset{treats}{\to }\ \mathrm{disease}\overset{caused\;by}{\to}\mathrm{protein} \) 190923 194
C22 \( \mathrm{compound}\overset{type\; of}{\to}\mathrm{ChEBI}\ \mathrm{type}\overset{type\; of}{\to}\mathrm{compound}\ \overset{binds\ to}{\to}\mathrm{protein}\ \overset{similar\;to}{\to}\mathrm{protein} \) 1463743 8639
C23 \( \mathrm{compound}\overset{type\; of}{\to}\mathrm{ChEBI}\ \mathrm{type}\overset{type\ of}{\to}\mathrm{compound}\overset{similar\ to}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein} \) 922257 8402
C24 \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{treated\ by}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein} \) 371971 162
C25 \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{treated\ by}{\to}\mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) 38708 91
C26 \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{treated\ by}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein} \) 493976 400
C27 \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{treated\ by}{\to}\mathrm{compound}\overset{similar\;to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein} \) 106013 710
C28 \( \mathrm{compound}\overset{induces}{\to}\mathrm{adverse}\ \mathrm{side}\ \mathrm{effect}\overset{induced\ by}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein} \) 1766464 1622
C29 \( \mathrm{compound}\overset{induces}{\to}\mathrm{adverse}\ \mathrm{side}\ \mathrm{effect}\overset{induced\ by}{\to}\mathrm{compound}\ \overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) 168841 106
C30 \( \mathrm{compound}\overset{induces}{\to}\mathrm{adverse}\ \mathrm{side}\ \mathrm{effect}\overset{induced\ by}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein} \) 1193429 5571
C31 \( \mathrm{compound}\overset{induces}{\to}\mathrm{adverse}\ \mathrm{side}\ \mathrm{effect}\overset{induced\ by}{\to}\mathrm{compound}\overset{similar\;to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein} \) 765725 2744
C32 \( \mathrm{compound}\overset{has\ part}{\to}\mathrm{substructure}\overset{part\ of}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein} \) 3465967 902
C33 \( \mathrm{compound}\overset{has\ part}{\to}\mathrm{substructure}\overset{part\ of}{\to}\mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) 355993 96
C34 \( \mathrm{compound}\overset{has\ part}{\to}\mathrm{substructure}\overset{part\ of}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein} \) 2175094 2753
C35 \( \mathrm{compound}\overset{has\ part}{\to}\mathrm{substructure}\overset{part\ of}{\to}\mathrm{compound}\overset{similar\;to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein} \) 1206786 12048
C36 \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein}\ \overset{has\ annotation}{\to}\mathrm{GO}\ \mathrm{annotation}\overset{annotation\ of}{\to}\mathrm{protein} \) 1064451402 1929
C37 \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein}\overset{has\ annotation}{\to}\mathrm{GO}\ \mathrm{annotation}\overset{annotation\ of}{\to}\mathrm{protein} \) 2280505 136
C38 \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein}\overset{has\ annotation}{\to}\mathrm{GO}\ \mathrm{annotation}\overset{annotation\ of}{\to}\mathrm{protein} \) 1480055439 50667
C39 \( \mathrm{compound}\overset{similar\ to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{has\ annotation}{\to}\mathrm{GO}\ \mathrm{annotation}\overset{annotation\ of}{\to}\mathrm{protein} \) 582316693 7765
C40 \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein}\overset{participates\ in}{\to}\mathrm{pathway}\overset{has\kern0.5em participants}{\to}\mathrm{protein} \) 246398750 2989
C41 \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein}\overset{participates\ in}{\to}\mathrm{pathway}\overset{has\ participants}{\to}\mathrm{protein} \) 486267 183
C42 \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein}\overset{\ participates\ in}{\to}\mathrm{pathway}\overset{\ has\kern0.5em participants}{\to}\mathrm{protein} \) 358346529 73327
C43 \( \mathrm{compound}\overset{similar\ to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{\ participates\kern0.5em in}{\to}\mathrm{pathway}\overset{\ has\kern0.5em participants}{\to}\mathrm{protein} \) 149299008 7543
C44 \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein}\overset{causes}{\to}\mathrm{disease}\ \overset{caused\kern0.5em by}{\to}\mathrm{protein} \) 7603639 44
C45 \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein}\overset{causes}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) 27193 63
C46 \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein}\overset{causes}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) 26747896 802
C47 \( \mathrm{compound}\overset{similar\;to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{causes}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) 4159753 313
C48 \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein}\overset{expressed\ in}{\to}\mathrm{tissue}\overset{expresses}{\to}\mathrm{protein} \) 222288200 453
C49 \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\;by}{\to}\mathrm{protein}\overset{expressed\ in}{\to}\mathrm{tissue}\overset{expresses}{\to}\mathrm{protein} \) 300620 27
C50 \( \mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein}\overset{expressed\ in}{\to}\mathrm{tissue}\overset{expresses}{\to}\mathrm{protein} \) 431134094 5974
C51 \( \mathrm{compound}\overset{similar\;to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{expressed\ in}{\to}\mathrm{tissue}\overset{expresses}{\to}\mathrm{protein} \) 117576353 2031
  1. a The number of non-zero elements in commuting matrix; b the max value of element in commuting matrix.