Table 2 The semantics and statistics of commuting matrixes
From: Predicting drug target interactions using meta-path-based semantic network analysis
Index | Semantics | Counta | Maxb |
|---|---|---|---|
C1 | \( \mathrm{compound}\ \overset{similar\;to}{\to}\;\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein} \) | 1995778 | 395 |
C2 | \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{interacts\; with}{\to}\mathrm{protein} \) | 4878633 | 20 |
C3 | \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{similar\ to}{\to}\mathrm{protein} \) | 30665527 | 84 |
C4 | \( \mathrm{compound}\ \overset{treats}{\to}\;\mathrm{disease}\overset{caused\;by}{\to}\mathrm{protein} \) | 6178 | 3 |
C5 | \( \mathrm{compound}\ \overset{similar\;to}{\to}\;\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein} \) | 15086309 | 934 |
C6 | \( \mathrm{compound}\ \overset{similar\;to}{\to}\;\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\ to}{\to}\mathrm{protein} \) | 49226573 | 1163 |
C7 | \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{binds\;to}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein} \) | 126339670 | 30400 |
C8 | \( \mathrm{compound}\ \overset{has\; part}{\to}\;\mathrm{substructure}\overset{part\; of}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein} \) | 922056 | 202 |
C9 | \( \mathrm{compound}\ \overset{has\; type}{\to}\;\mathrm{ChEBI}\ \mathrm{type}\overset{type\ of}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein} \) | 709802 | 324 |
C10 | \( \mathrm{compound}\ \overset{induces}{\to}\;\mathrm{adverse}\ \mathrm{side}\ \mathrm{effect}\overset{induced\kern0.5em by}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein} \) | 420616 | 194 |
C11 | \( \mathrm{compound}\ \overset{treats}{\to}\;\mathrm{disease}\overset{treated\;by}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein} \) | 68479 | 25 |
C12 | \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{has\; annotation}{\to}\mathrm{GO}\ \mathrm{annotation}\overset{annotation\ of}{\to}\mathrm{protein} \) | 316095950 | 335 |
C13 | \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{participates\; in}{\to}\mathrm{pathway}\overset{has\ participants}{\to}\mathrm{protein} \) | 82834409 | 328 |
C14 | \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{expressed\; in}{\to}\mathrm{tissue}\overset{expresses}{\to}\mathrm{protein} \) | 53586080 | 76 |
C15 | \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{causes}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) | 1360337 | 10 |
C16 | \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{binds\;to}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein}\overset{interact\ with}{\to}\mathrm{protein} \) | 522513250 | 142290 |
C17 | \( \mathrm{compound}\ \overset{binds\;to}{\to}\;\mathrm{protein}\overset{binds\;to}{\to}\mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) | 12963831 | 498 |
C18 | \( \mathrm{compound}\ \overset{binds\;to}{\to}\mathrm{protein}\ \overset{binds\;to}{\to}\mathrm{compound}\ \overset{similar\;to}{\to}\mathrm{compound}\ \overset{binds\;to}{\to}\mathrm{protein} \) | 201052081 | 777576 |
C19 | \( \mathrm{compound}\ \overset{binds\;to}{\to}\mathrm{protein}\ \overset{binds\;to}{\to}\mathrm{compound}\ \overset{binds\;to}{\to}\mathrm{protein}\ \overset{similar\;to}{\to}\mathrm{protein} \) | 356122463 | 445332 |
C20 | \( \mathrm{compound}\ \overset{type\; of}{\to}\mathrm{ChEBI}\ \mathrm{type}\ \overset{type\; of}{\to}\mathrm{compound}\ \overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein} \) | 2333739 | 2711 |
C21 | \( \mathrm{compound}\ \overset{type\; of}{\to}\mathrm{ChEBI}\ \mathrm{type}\ \overset{type\; of}{\to}\mathrm{compound}\overset{treats}{\to }\ \mathrm{disease}\overset{caused\;by}{\to}\mathrm{protein} \) | 190923 | 194 |
C22 | \( \mathrm{compound}\overset{type\; of}{\to}\mathrm{ChEBI}\ \mathrm{type}\overset{type\; of}{\to}\mathrm{compound}\ \overset{binds\ to}{\to}\mathrm{protein}\ \overset{similar\;to}{\to}\mathrm{protein} \) | 1463743 | 8639 |
C23 | \( \mathrm{compound}\overset{type\; of}{\to}\mathrm{ChEBI}\ \mathrm{type}\overset{type\ of}{\to}\mathrm{compound}\overset{similar\ to}{\to}\mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein} \) | 922257 | 8402 |
C24 | \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{treated\ by}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein} \) | 371971 | 162 |
C25 | \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{treated\ by}{\to}\mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) | 38708 | 91 |
C26 | \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{treated\ by}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein} \) | 493976 | 400 |
C27 | \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{treated\ by}{\to}\mathrm{compound}\overset{similar\;to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein} \) | 106013 | 710 |
C28 | \( \mathrm{compound}\overset{induces}{\to}\mathrm{adverse}\ \mathrm{side}\ \mathrm{effect}\overset{induced\ by}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein} \) | 1766464 | 1622 |
C29 | \( \mathrm{compound}\overset{induces}{\to}\mathrm{adverse}\ \mathrm{side}\ \mathrm{effect}\overset{induced\ by}{\to}\mathrm{compound}\ \overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) | 168841 | 106 |
C30 | \( \mathrm{compound}\overset{induces}{\to}\mathrm{adverse}\ \mathrm{side}\ \mathrm{effect}\overset{induced\ by}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein} \) | 1193429 | 5571 |
C31 | \( \mathrm{compound}\overset{induces}{\to}\mathrm{adverse}\ \mathrm{side}\ \mathrm{effect}\overset{induced\ by}{\to}\mathrm{compound}\overset{similar\;to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein} \) | 765725 | 2744 |
C32 | \( \mathrm{compound}\overset{has\ part}{\to}\mathrm{substructure}\overset{part\ of}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein} \) | 3465967 | 902 |
C33 | \( \mathrm{compound}\overset{has\ part}{\to}\mathrm{substructure}\overset{part\ of}{\to}\mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) | 355993 | 96 |
C34 | \( \mathrm{compound}\overset{has\ part}{\to}\mathrm{substructure}\overset{part\ of}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein} \) | 2175094 | 2753 |
C35 | \( \mathrm{compound}\overset{has\ part}{\to}\mathrm{substructure}\overset{part\ of}{\to}\mathrm{compound}\overset{similar\;to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein} \) | 1206786 | 12048 |
C36 | \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein}\ \overset{has\ annotation}{\to}\mathrm{GO}\ \mathrm{annotation}\overset{annotation\ of}{\to}\mathrm{protein} \) | 1064451402 | 1929 |
C37 | \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein}\overset{has\ annotation}{\to}\mathrm{GO}\ \mathrm{annotation}\overset{annotation\ of}{\to}\mathrm{protein} \) | 2280505 | 136 |
C38 | \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein}\overset{has\ annotation}{\to}\mathrm{GO}\ \mathrm{annotation}\overset{annotation\ of}{\to}\mathrm{protein} \) | 1480055439 | 50667 |
C39 | \( \mathrm{compound}\overset{similar\ to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{has\ annotation}{\to}\mathrm{GO}\ \mathrm{annotation}\overset{annotation\ of}{\to}\mathrm{protein} \) | 582316693 | 7765 |
C40 | \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein}\overset{participates\ in}{\to}\mathrm{pathway}\overset{has\kern0.5em participants}{\to}\mathrm{protein} \) | 246398750 | 2989 |
C41 | \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein}\overset{participates\ in}{\to}\mathrm{pathway}\overset{has\ participants}{\to}\mathrm{protein} \) | 486267 | 183 |
C42 | \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein}\overset{\ participates\ in}{\to}\mathrm{pathway}\overset{\ has\kern0.5em participants}{\to}\mathrm{protein} \) | 358346529 | 73327 |
C43 | \( \mathrm{compound}\overset{similar\ to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{\ participates\kern0.5em in}{\to}\mathrm{pathway}\overset{\ has\kern0.5em participants}{\to}\mathrm{protein} \) | 149299008 | 7543 |
C44 | \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein}\overset{causes}{\to}\mathrm{disease}\ \overset{caused\kern0.5em by}{\to}\mathrm{protein} \) | 7603639 | 44 |
C45 | \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein}\overset{causes}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) | 27193 | 63 |
C46 | \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein}\overset{causes}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) | 26747896 | 802 |
C47 | \( \mathrm{compound}\overset{similar\;to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{causes}{\to}\mathrm{disease}\overset{caused\ by}{\to}\mathrm{protein} \) | 4159753 | 313 |
C48 | \( \mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{interacts\ with}{\to}\mathrm{protein}\overset{expressed\ in}{\to}\mathrm{tissue}\overset{expresses}{\to}\mathrm{protein} \) | 222288200 | 453 |
C49 | \( \mathrm{compound}\overset{treats}{\to}\mathrm{disease}\overset{caused\;by}{\to}\mathrm{protein}\overset{expressed\ in}{\to}\mathrm{tissue}\overset{expresses}{\to}\mathrm{protein} \) | 300620 | 27 |
C50 | \( \mathrm{compound}\overset{binds\ to}{\to}\mathrm{protein}\overset{similar\;to}{\to}\mathrm{protein}\overset{expressed\ in}{\to}\mathrm{tissue}\overset{expresses}{\to}\mathrm{protein} \) | 431134094 | 5974 |
C51 | \( \mathrm{compound}\overset{similar\;to}{\to}\mathrm{compound}\overset{binds\;to}{\to}\mathrm{protein}\overset{expressed\ in}{\to}\mathrm{tissue}\overset{expresses}{\to}\mathrm{protein} \) | 117576353 | 2031 |