Table 2 Power analysis using simulated phenotypes and SNP pairs randomly selected from the Rotterdam Study
|  | Threshold 5 × 10-2 | Threshold 5 × 10-8 | Threshold 5 × 10-11 | ||||||
|---|---|---|---|---|---|---|---|---|---|
N | β | MAF | a | b | GCDH | a | b | GCDH | GCDH |
8000 | 0.50 | 0.01 | 0.05 | 0.05 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 |
8000 | 0.50 | 0.02 | 0.09 | 0.09 | 0.53 | 0.00 | 0.00 | 0.00 | 0.00 |
8000 | 0.50 | 0.03 | 0.20 | 0.13 | 0.84 | 0.00 | 0.00 | 0.04 | 0.00 |
8000 | 0.50 | 0.04 | 0.31 | 0.40 | 1.00 | 0.00 | 0.00 | 0.22 | 0.04 |
8000 | 0.50 | 0.05 | 0.42 | 0.45 | 1.00 | 0.00 | 0.00 | 0.40 | 0.15 |
8000 | 0.70 | 0.01 | 0.04 | 0.09 | 0.45 | 0.00 | 0.00 | 0.00 | 0.00 |
8000 | 0.70 | 0.02 | 0.11 | 0.09 | 0.84 | 0.00 | 0.00 | 0.02 | 0.00 |
8000 | 0.70 | 0.03 | 0.18 | 0.29 | 1.00 | 0.00 | 0.00 | 0.25 | 0.04 |
8000 | 0.70 | 0.04 | 0.47 | 0.45 | 1.00 | 0.00 | 0.00 | 0.65 | 0.33 |
8000 | 0.70 | 0.05 | 0.67 | 0.75 | 1.00 | 0.00 | 0.00 | 0.95 | 0.76 |
8000 | 0.90 | 0.01 | 0.05 | 0.09 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 |
8000 | 0.90 | 0.02 | 0.20 | 0.15 | 0.96 | 0.00 | 0.00 | 0.09 | 0.00 |
8000 | 0.90 | 0.03 | 0.49 | 0.36 | 1.00 | 0.00 | 0.00 | 0.53 | 0.20 |
8000 | 0.90 | 0.04 | 0.56 | 0.82 | 1.00 | 0.02 | 0.02 | 0.98 | 0.84 |
8000 | 0.90 | 0.05 | 0.87 | 0.93 | 1.00 | 0.06 | 0.02 | 1.00 | 0.98 |
8000 | 1.10 | 0.01 | 0.02 | 0.09 | 0.67 | 0.00 | 0.00 | 0.00 | 0.00 |
8000 | 1.10 | 0.02 | 0.27 | 0.18 | 1.00 | 0.00 | 0.00 | 0.27 | 0.07 |
8000 | 1.10 | 0.03 | 0.57 | 0.61 | 1.00 | 0.00 | 0.00 | 0.98 | 0.78 |
8000 | 1.10 | 0.04 | 0.80 | 0.84 | 1.00 | 0.02 | 0.00 | 1.00 | 1.00 |
8000 | 1.10 | 0.05 | 1.00 | 0.98 | 1.00 | 0.06 | 0.15 | 1.00 | 1.00 |
8000 | 1.30 | 0.01 | 0.07 | 0.04 | 0.85 | 0.00 | 0.00 | 0.00 | 0.00 |
8000 | 1.30 | 0.02 | 0.25 | 0.31 | 1.00 | 0.00 | 0.00 | 0.44 | 0.20 |
8000 | 1.30 | 0.03 | 0.62 | 0.67 | 1.00 | 0.00 | 0.00 | 1.00 | 0.96 |
8000 | 1.30 | 0.04 | 0.89 | 0.93 | 1.00 | 0.02 | 0.00 | 1.00 | 1.00 |
8000 | 1.30 | 0.05 | 1.00 | 0.98 | 1.00 | 0.33 | 0.36 | 1.00 | 1.00 |
8000 | 1.50 | 0.01 | 0.13 | 0.09 | 0.85 | 0.00 | 0.00 | 0.07 | 0.00 |
8000 | 1.50 | 0.02 | 0.25 | 0.40 | 1.00 | 0.00 | 0.00 | 0.76 | 0.35 |
8000 | 1.50 | 0.03 | 0.78 | 0.78 | 1.00 | 0.00 | 0.00 | 1.00 | 1.00 |
8000 | 1.50 | 0.04 | 0.96 | 1.00 | 1.00 | 0.13 | 0.13 | 1.00 | 1.00 |
8000 | 1.50 | 0.05 | 1.00 | 1.00 | 1.00 | 0.39 | 0.59 | 1.00 | 1.00 |
11000 | 0.50 | 0.01 | 0.00 | 0.05 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 |
11000 | 0.50 | 0.02 | 0.04 | 0.15 | 0.65 | 0.00 | 0.00 | 0.00 | 0.00 |
11000 | 0.50 | 0.03 | 0.18 | 0.20 | 0.96 | 0.00 | 0.00 | 0.00 | 0.00 |
11000 | 0.50 | 0.04 | 0.49 | 0.35 | 1.00 | 0.00 | 0.00 | 0.27 | 0.05 |
11000 | 0.50 | 0.05 | 0.56 | 0.60 | 1.00 | 0.00 | 0.00 | 0.78 | 0.44 |
11000 | 0.70 | 0.01 | 0.04 | 0.04 | 0.53 | 0.00 | 0.00 | 0.02 | 0.00 |
11000 | 0.70 | 0.02 | 0.11 | 0.20 | 0.89 | 0.00 | 0.00 | 0.07 | 0.00 |
11000 | 0.70 | 0.03 | 0.35 | 0.29 | 1.00 | 0.00 | 0.00 | 0.42 | 0.07 |
11000 | 0.70 | 0.04 | 0.51 | 0.62 | 1.00 | 0.00 | 0.00 | 0.95 | 0.76 |
11000 | 0.70 | 0.05 | 0.87 | 0.87 | 1.00 | 0.02 | 0.02 | 1.00 | 0.98 |
11000 | 0.90 | 0.01 | 0.02 | 0.04 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 |
11000 | 0.90 | 0.02 | 0.20 | 0.35 | 1.00 | 0.00 | 0.00 | 0.33 | 0.09 |
11000 | 0.90 | 0.03 | 0.49 | 0.40 | 1.00 | 0.00 | 0.00 | 0.85 | 0.56 |
11000 | 0.90 | 0.04 | 0.87 | 0.75 | 1.00 | 0.00 | 0.00 | 1.00 | 0.96 |
11000 | 0.90 | 0.05 | 0.96 | 0.98 | 1.00 | 0.02 | 0.05 | 1.00 | 1.00 |
11000 | 1.10 | 0.01 | 0.13 | 0.05 | 0.76 | 0.00 | 0.00 | 0.00 | 0.00 |
11000 | 1.10 | 0.02 | 0.35 | 0.27 | 1.00 | 0.00 | 0.00 | 0.58 | 0.20 |
11000 | 1.10 | 0.03 | 0.53 | 0.56 | 1.00 | 0.00 | 0.00 | 1.00 | 0.91 |
11000 | 1.10 | 0.04 | 0.93 | 0.91 | 1.00 | 0.02 | 0.02 | 1.00 | 1.00 |
11000 | 1.10 | 0.05 | 1.00 | 1.00 | 1.00 | 0.27 | 0.24 | 1.00 | 1.00 |
11000 | 1.30 | 0.01 | 0.13 | 0.07 | 0.91 | 0.00 | 0.00 | 0.02 | 0.00 |
11000 | 1.30 | 0.02 | 0.41 | 0.46 | 1.00 | 0.00 | 0.00 | 0.91 | 0.61 |
11000 | 1.30 | 0.03 | 0.76 | 0.78 | 1.00 | 0.00 | 0.00 | 1.00 | 1.00 |
11000 | 1.30 | 0.04 | 0.98 | 1.00 | 1.00 | 0.11 | 0.16 | 1.00 | 1.00 |
11000 | 1.30 | 0.05 | 1.00 | 1.00 | 1.00 | 0.55 | 0.62 | 1.00 | 1.00 |
11000 | 1.50 | 0.01 | 0.04 | 0.11 | 0.87 | 0.00 | 0.00 | 0.04 | 0.00 |
11000 | 1.50 | 0.02 | 0.47 | 0.44 | 1.00 | 0.00 | 0.00 | 0.96 | 0.76 |
11000 | 1.50 | 0.03 | 0.89 | 0.91 | 1.00 | 0.02 | 0.05 | 1.00 | 1.00 |
11000 | 1.50 | 0.04 | 0.98 | 0.96 | 1.00 | 0.18 | 0.24 | 1.00 | 1.00 |
11000 | 1.50 | 0.05 | 1.00 | 1.00 | 1.00 | 0.85 | 0.87 | 1.00 | 1.00 |