Gene signature-based mapping of immunological systems and diseases

BMC Bioinformatics

Table 4 Immune disease gene signatures and genetic linked genes

Disease category	# of GWAS gene	# of DEG	# of overlapped gene
COPD	113	3137	11
Asthma	195	1783	13
Dermatitis	53	2314	5
Psoriasis	56	1144	9*
IBD	525	4095	116
Lupus	181	3696	33
Arthritis	301	5227	83
Sclerosis	343	2041	28
T1D	166	3144	20

“# of GWAS Gene” indicates the number of genes reported in GWAS Catalog that are linked to the related disease category; “# of DEG” indicates the number of Differentially Expressed Genes present in any related disease gene sets; “# of Overlapped Gene” indicates the number of genes existing in both “GWAS Gene” and “DEG”. * indicates that the overlapping is significant based on Chi-square test

ISSN: 1471-2105