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Table 3 Reconstruction of Ikaros regulatory program in PBMC data collection. For each method the number of predicted and correctly retrieved interactions is reported, along with the odds ratio, precision and recall performances (see text for further details on these metrics)

From: A comparative evaluation of data-merging and meta-analysis methods for reconstructing gene-gene interactions

Method # Predicted interactions # Retrieved interactions Odds ratio Odds ratio significance Precision Recall
Combat 82 21 2.2726 0.00022 0.2561 0.0093
Fixed-Effect 102 21 1.827 0.00440 0.2059 0.0093
Single-Dataset 387 70 1.6513 [<0.0001 - 0.65914] 0.1861 0.0310
No-Correction 113 21 1.6491 0.01435 0.185841 0.0092
  1. Odds ratio statistical significance is assessed through the hypergeometric test. For the Single-Dataset approach distinct performances and significance p-values were computed for each dataset, summarized here as a weighted average of the performance and with the interval spanned by the p-values, respectively