Fig. 7

Application of a Gaussian filter (Fig. 6) to ChIP-seq data. In the first step, the normalised coverage for reads mapping to the forward (green) and reverse (red) strand are computed. Later, for a genomic position, the cross-correlation between the forward coverage and the filter shape centred at that position is computed. An analogous procedure is performed for reads mapping to the reverse strand. Their sum constitutes the Peak Shape Score (blue)