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Fig. 4 | BMC Bioinformatics

Fig. 4

From: Analysis tools for the interplay between genome layout and regulation

Fig. 4

Map of periodic regions, or “Chromogram”, of CRP target operons. This graph visualises regions of the whole genome which contain periodic genomic features. The horizontal axis spans the whole genome length and the vertical axis is used only to order segments based on their total length. Each horizontal bar designates a region of the genome where the genomic features of interest appear to be significantly periodic. On each bar, p is the length of the period and g the number of genes contributing to that period. The extremities of the bar specify the region, the thickness the number of genomic features which are contained in this region and the colour gradient is drawn according to the p-value of the period. The range of p-values is depicted in the legend, the p-value cut-off is a user specified parameter. Vertical dashed lines (also user specified) represent the borders of the E. coli macrodomains. Here we observed a noticeable overlap of the boundaries of the periodic regions for the E. coli CRP regulated operons (the blue ticks along the horizontal axis) with the region which spans from the ori to the ter macrodomain. (The plot was generated by 116 operons or genes (90 data points after the proximity removal) and mapping p-value cut-off 0.0005)

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