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Fig. 3 | BMC Bioinformatics

Fig. 3

From: QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

Fig. 3

QUADrATiC Workflow and GUI. Step 1: the query signature is defined as a pair of lists of up and down-regulated Affymetrix HG-U133A probe identifiers. Step 2: an analysis run is defined by choosing the query signature, the treatment set type (grouped by drug, or by drug and cell line), and the number of random signatures to be used to estimate the p-value of the connections; the progress bar updates every 30 seconds. Step 3: View the table of significant connections. Step 4: Summary visualizations are available as a bubble chart representing the top connections, or a summary of drugs and cell lines (for treatment sets defined by drug and cell line). Step 5: View a heatmap showing the relative contribution of each probe in the signature

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