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Fig. 10 | BMC Bioinformatics

Fig. 10

From: DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing

Fig. 10

Predicted sunitinib drug action network on AD. Direct protein targets predicted by DGE-NET for sunitinib that are also significantly AD-modulated are in large orange and blue circles. Blue circles are genes overexpressed in AD with statistical significance, while orange circles are protein partners of those genes. Pink circles are KEGG pathways, and purple circles are GO cellular functions, enriched at p-value < .01 in the up-regulated genes of AD. The top 10 significantly enriched cellular functions and pathways are detailed in large ovals

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