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Fig. 3 | BMC Bioinformatics

Fig. 3

From: DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing

Fig. 3

Hypergeometric test schematic for drug-disease association at each level of biological activity. Each drug is associated with a given disease at each level of biological action by the hypergeometric test. a Given a gene, pathway, function, or indirect protein ‘universe’, the hypergeometric test allows one to determine the probability that coincident drawings between two samples drawn from that universe is due to random chance. Therefore, the statistical significance of having hits (common items) between drug-associated biological factors and disease-associated factors is derived. b Computation of hypergeometric p-values and subsequent normalization for integration into cumulative score. c Computation of drug-disease association Z-score. d Ranking scheme by drug-disease association Z-score in descending order. That is, Zi exhibits the highest system-wide statistical association (highest-magnitude Z-score), followed by Zi + 1, Zi + 2, Zi + 3, and so forth

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