Fig. 4

Formation of drug-target (DT) disease networks. A random sample of drugs with predicted protein targets known to be associated with a disease in OMIM were selected to illustrate the process of associating drugs with diseases. a Drugs (orange circle nodes) are connected using a charcoal dashed edge to predicted protein targets (square nodes); the protein targets are connected using a solid tan edge to a disease if the protein has disease genes associated with the disease. Pink nodes represent proteins associated with multiple diseases, while green nodes represent proteins associated with a single. These interactions were used to form a drug-target disease network. b The drugs (orange circle nodes) are connected to a disease if a predicted drug-target has disease genes associated with the disease