Table 1 Validations of predicted drug-pathway associations via the KEGG Drug database
Drug | KEGG Drug ID | KEGG Pathway |
|---|---|---|
Acetohexamide | D00219 | Type II diabetes mellitus |
Aripiprazole | D01164 | Gap junction |
Bezafibrate | D01366 | Adipocytokine signaling pathway |
Bicalutamide | D00961 | Pathways in cancer, Prostate cancer |
Candesartan | D00626 | Vascular smooth muscle contraction |
Carvedilol | D00255 | Vascular smooth muscle contraction |
Celecoxib | D00567 | VEGF signaling pathway |
Cilostazol | D01896 | Insulin signaling pathway |
Clozapine | D00283 | Gap junction |
Conivaptan | D01236 | Vascular smooth muscle contraction |
Danazol | D00289 | Oocyet meiosis, Progesterone-mediated oocyte maturation, Pathways in cancer |
Dasatinib | D03658 | MAPK signaling pathway, ErbB signaling pathway, Cytokine-cytokine receptor interaction, VEGF signaling pathway, Pathways in cancer, Chronic myeloid leukemia |
Diflunisal | D00130 | VEGF signaling pathway |
Domperidone | D01745 | Gap junction |
Droperidol | D00308 | Gap junction |
Drospirenone | D03917 | Aldosterone-regulated sodium transport |
Dydrogesterone | D01217 | Oocyte meiosis, Progesterone-mediated oocyte meiosis |
Eltrombopag | D03978 | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
Epoprostenol | D00106 | Vascular smooth muscle contraction |
Eprosartan | D04040 | Vascular smooth muscle contraction |
Erlotinib | D07907 | MAPK signaling pathway, ErbB signaling pathway, Cytokine-cytokine receptor interaction, Pathways in cancer, Pancreatic cancer, Non-small cell lung cancer |
Fenofibrate | D00565 | Adipocytokine signaling pathway |
Floxuridine | D04197 | Pyrimidine metabolism |
Flupenthixol | D01044 | Gap |
Flurbiprofen | D00330 | VEGF signaling pathway |
Flutamide | D00586 | Pathways in cancer, Prostate cancer |
Gemcitabine | D02368 | Purine metabolism, Pyrimidine metabolism |
Gliclazide | D01599 | Type II diabetes mellitus |
Glipizide | D00335 | Type II diabetes mellitus |
Haloperidol | D00136 | Gap junction |
Imatinib | D01441 | MAPK signaling pathway, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer, Chronic myeloid leukemia |
Indacaterol | D09318 | Endocytosis |
Indomethacin | D00141 | VEGF signaling pathway |
Ketoprofen | D00132 | VEGF signaling pathway |
Lapatinib | D04024 | MAPK signaling pathway, ErbB signaling pathway, Cytokine-cytokine receptor pathway, Pathways in cancer |
Levonorgestrel | D00950 | Oocyte meiosis, Progesterone-mediated oocyte maturation |
Losartan | D08146 | Vascular smooth muscle contraction |
Methysergide | D02357 | Gap junction |
Milrinone | D00417 | Progesterone-mediated oocyte maturation |
Mitiglinide | D01854 | Type II diabetes mellitus |
Naproxen | D00118 | VEGF signaling pathway |
Nilutamide | D00965 | Pathways in cancer, Prostate cancer |
Norethindrone | D00182 | Oocyte meiosis, Progesterone-mediated oocyte maturation |
Olmesartan | D01204 | Vascular smooth muscle contraction |
Oxaprozin | D00463 | VEGF signaling pathway |
Piroxicam | D00127 | VEGF signaling pathway |
Progesterone | D00066 | Oocyte meiosis, Progesterone-mediated oocyte maturation |
Propericiazine | D01485 | Gap junction |
Regadenoson | D05711 | Vascular smooth muscle contraction |
Risperidone | D00426 | Vascular smooth muscle contraction, Gap junction |
Salsalate | D00428 | VEGF signaling pathway |
Silodosin | D01965 | Vascular smooth muscle contraction |
Sorafenib | D08524 | MAPK signaling pathway, ErbB signaling pathway, Cytokine-cytokine receptor interaction, Chemokine signaling pathway, mTOR signaling pathway, VEGF signaling pathway, Natural killer cell mediated cytotoxicity, Pathways in cancer, Renal cell carcinoma |
Sulindac | D00120 | VEGF signaling pathway |
Sunitinib | D06402 | MAPK signaling pathway, Cytokine-cytokine receptor interaction, VEGF signaling pathway, Pathways in cancer |
Telmisartan | D00627 | Vascular smooth muscle contraction |
Testosterone | D00075 | Pathways in cancer, Prostate cancer |
Vandetanib | D06407 | MAPK signaling pathway, ErbB signaling pathway, Cytokine-cytokine receptor interaction, VEGF signaling pathway, Pathways in cancer |