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Table 1 Validations of predicted drug-pathway associations via the KEGG Drug database

From: DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing

Drug KEGG Drug ID KEGG Pathway
Acetohexamide D00219 Type II diabetes mellitus
Aripiprazole D01164 Gap junction
Bezafibrate D01366 Adipocytokine signaling pathway
Bicalutamide D00961 Pathways in cancer, Prostate cancer
Candesartan D00626 Vascular smooth muscle contraction
Carvedilol D00255 Vascular smooth muscle contraction
Celecoxib D00567 VEGF signaling pathway
Cilostazol D01896 Insulin signaling pathway
Clozapine D00283 Gap junction
Conivaptan D01236 Vascular smooth muscle contraction
Danazol D00289 Oocyet meiosis, Progesterone-mediated oocyte maturation, Pathways in cancer
Dasatinib D03658 MAPK signaling pathway, ErbB signaling pathway, Cytokine-cytokine receptor interaction, VEGF signaling pathway, Pathways in cancer, Chronic myeloid leukemia
Diflunisal D00130 VEGF signaling pathway
Domperidone D01745 Gap junction
Droperidol D00308 Gap junction
Drospirenone D03917 Aldosterone-regulated sodium transport
Dydrogesterone D01217 Oocyte meiosis, Progesterone-mediated oocyte meiosis
Eltrombopag D03978 Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
Epoprostenol D00106 Vascular smooth muscle contraction
Eprosartan D04040 Vascular smooth muscle contraction
Erlotinib D07907 MAPK signaling pathway, ErbB signaling pathway, Cytokine-cytokine receptor interaction, Pathways in cancer, Pancreatic cancer, Non-small cell lung cancer
Fenofibrate D00565 Adipocytokine signaling pathway
Floxuridine D04197 Pyrimidine metabolism
Flupenthixol D01044 Gap
Flurbiprofen D00330 VEGF signaling pathway
Flutamide D00586 Pathways in cancer, Prostate cancer
Gemcitabine D02368 Purine metabolism, Pyrimidine metabolism
Gliclazide D01599 Type II diabetes mellitus
Glipizide D00335 Type II diabetes mellitus
Haloperidol D00136 Gap junction
Imatinib D01441 MAPK signaling pathway, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer, Chronic myeloid leukemia
Indacaterol D09318 Endocytosis
Indomethacin D00141 VEGF signaling pathway
Ketoprofen D00132 VEGF signaling pathway
Lapatinib D04024 MAPK signaling pathway, ErbB signaling pathway, Cytokine-cytokine receptor pathway, Pathways in cancer
Levonorgestrel D00950 Oocyte meiosis, Progesterone-mediated oocyte maturation
Losartan D08146 Vascular smooth muscle contraction
Methysergide D02357 Gap junction
Milrinone D00417 Progesterone-mediated oocyte maturation
Mitiglinide D01854 Type II diabetes mellitus
Naproxen D00118 VEGF signaling pathway
Nilutamide D00965 Pathways in cancer, Prostate cancer
Norethindrone D00182 Oocyte meiosis, Progesterone-mediated oocyte maturation
Olmesartan D01204 Vascular smooth muscle contraction
Oxaprozin D00463 VEGF signaling pathway
Piroxicam D00127 VEGF signaling pathway
Progesterone D00066 Oocyte meiosis, Progesterone-mediated oocyte maturation
Propericiazine D01485 Gap junction
Regadenoson D05711 Vascular smooth muscle contraction
Risperidone D00426 Vascular smooth muscle contraction, Gap junction
Salsalate D00428 VEGF signaling pathway
Silodosin D01965 Vascular smooth muscle contraction
Sorafenib D08524 MAPK signaling pathway, ErbB signaling pathway, Cytokine-cytokine receptor interaction, Chemokine signaling pathway, mTOR signaling pathway, VEGF signaling pathway, Natural killer cell mediated cytotoxicity, Pathways in cancer, Renal cell carcinoma
Sulindac D00120 VEGF signaling pathway
Sunitinib D06402 MAPK signaling pathway, Cytokine-cytokine receptor interaction, VEGF signaling pathway, Pathways in cancer
Telmisartan D00627 Vascular smooth muscle contraction
Testosterone D00075 Pathways in cancer, Prostate cancer
Vandetanib D06407 MAPK signaling pathway, ErbB signaling pathway, Cytokine-cytokine receptor interaction, VEGF signaling pathway, Pathways in cancer