Fig. 1From: A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mappingFlow chart of the two stage process. The output from stage 1 is a ranked list of significant genes with their regulation status (direction of differential expression in the treatment condition relative to the control). This is used as input to stage 2, gene signature progression. Starting from k=1, the top k genes are fed to sscMap as a query signature to pull out significant drugs. This process is run iteratively with increasing k until a pre-set target FDR is achieved for the returned significant drugsBack to article page