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Table 2 The significant connections returned from sscMap using the HDACi optimal gene signature (k=5) obtained from the “simulated experiment”

From: A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mapping

Compound

Replicates

cscore

p value

zscore

SM

PS

Sodium phenylbutyrate

7

0.684

5.0E-06

7.93

1

1

Trichostatin A

182

0.822

5.0E-06

6.18

1

1

Scriptaid

3

0.928

5.0E-06

5.39

1

1

Valproic acid

57

0.323

1.0E-05

5.31

1

1

Rifabutin

3

0.880

5.0E-06

5.21

1

1

Vorinostat

12

0.890

5.0E-06

5.19

1

1

MS-275

2

0.954

5.0E-06

4.30

1

1

Withaferin A

4

0.729

2.0E-05

3.97

1

1

HC toxin

1

0.928

5.0E-06

3.59

1

1

2-deoxy-D-glucose

1

0.902

1.0E-05

3.49

1

1

  1. All 7 known HDAC inhibitors, including those not used in signature generation, were pulled out. SM (significance mark) =1 indicates that the connection p value is less than the preset threshold E fp /N sets =1/1309≈7.6×10−4; PS (perturbation stability) is also shown here