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Table 3 The significant connections returned from sscMap using the Lung cancer optimal gene signature obtained from the gene signature progression process in the case study with GSE19804 dataset

From: A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mapping

Compound Replicates cscore p value zscore SM PS
Trichostatin A 182 –0.072 1.0E-05 –4.33 1 1.00
Rofecoxib 6 –0.047 6.0E-05 –4.29 1 1.00
Calmidazolium 2 –0.110 1.0E-05 –4.23 1 1.00
MS-275 2 –0.108 7.0E-05 –3.87 1 1.00
Rifabutin 3 –0.080 7.0E-05 –3.76 1 1.00
Exemestane 1 –0.113 2.8E-04 –3.50 1 1.00
STOCK1N-35696 2 –0.082 3.0E-04 –3.38 1 1.00
1,5-isoquinolinediol 1 –0.107 4.5E-04 –3.31 1 1.00
Pioglitazone 11 –0.030 3.4E-04 –3.33 1 0.99
Gefitinib 1 –0.105 5.8E-04 –3.23 1 0.93
  1. SM (significance mark) =1 indicates that the connection p value is less than the preset threshold E fp /N sets =1/1309≈7.6×10−4; PS (perturbation stability) is also shown here