Table 1 Summary of reproducing results from the literature using RNArobo. Searches were extended by allowing for insertions in structurally conserved elements that are known to tolerate single base insertions. This extension led to improved sensitivity and yielded several new putatively functional ribozymes

In vitro selected library

GTP apt. class I

9

yes

(∼65 kBp scanned)

GTP apt. class I w/ ins

10

yes [42]

novel hit

Yarrowia lipolytica

HHR I (4 bp)

1

Yli-1-3

(∼41 MBp scanned)

HHR I (4 bp) w/ ins

15

Yli-1-3 through Yli-1-11

HHR I (3 bp)

4

Yli-1-3 and Yli-1-13

HHR I (3 bp) w/ ins

54

Yli-1-3 through Yli-1-11,

novel family

and Yli-1-13 [16]

(10 hits)

Bacillus cereus

HHR II

1

Bce-1-1

(∼11 MBp scanned)

HHR II w/ ins

4

Bce-1-1 [16]

Anopheles gambiae chr2L

HDV (loose P4)

7

Agam-1-1

(∼98 MBp bases scanned)

HDV (loose P4) w/ ins

36

Agam-1-1 and Agam-1-2 [7]

Strongylocentrotus purpuratus

HDV (stem P4)

11

yes

(∼2.1 GBp scanned)

HDV (stem P4) w/ ins

11

yes

HDV (loose P4) + FF

15

yes

HDV (loose P4) w/ ins + FF

16

yes [7]

novel hit