Fig. 2
From: Context-specific functional module based drug efficacy prediction
System overview. 1. We constructed the backbone network. 2. We made cell line-specific networks using gene expression data of cell lines from NCI60 and the backbone network. 3. We identified cell line-specific function modules applying network clustering algorithm on the cell line specific network. 4. We identified context-specific functions by calculating module similarity of each functional module. 5. We assigned cell line-specific functional modules on cell line-specific functions to make learning models for predicting the efficacy of drugs. 6. We predicted the efficacy of drugs