Fig. 3
From: Prediction of scaffold proteins based on protein interaction and domain architectures
Models of AXIN1 scaffold protein and PIK3R1 scaffold protein candidate. a AXIN1 is a known scaffold protein and AXIN1 interacts with GSK3B and CTNNB1 using RGS and Axin b-cat bind domain respectively. CTNNB1 is related activation of glucose import. Through gene expression analysis, AXIN1 is down regulated in type 2 diabetes. b PIK3R1 is predicted as a scaffold protein. RIK3R1 can recruit GAB1 and PIK3CA using SH2 domains. PIK3CA is known as a gene related to malignant neoplasm of blast and inhibits apoptotic function. Protein expression of PIK3R1 is not detected in normal breast cell, however it is highly expressed in breast cancer cell