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Fig. 7 | BMC Bioinformatics

Fig. 7

From: Identification of recurrent focal copy number variations and their putative targeted driver genes in ovarian cancer

Fig. 7

Effects of copy number change on RNA expression for cancer drivers and non-cancer drivers. The vertical axis shows effect size of copy number change on RNA expression as boxplots. In the focal gain regions, each data point used in the boxplots were computed from the average log-fold change of mRNA expression of a gene between tumor samples with focal gain and tumor samples without focal gain. In the focal loss regions, each data point used in the boxplots were computed from the average log-fold change of mRNA expression of a gene between tumor samples without focal loss and tumor samples with focal loss. The boxplots were generated from data on three different platforms: RNAseq, Agilent 244 K and Affymetrix U133A, corresponding to the panels on the left, middle and right, respectively. The differences in the effect sizes are significant (p-values =0.012, 0.0059, 0.020, for the left, middle and right panels, respectively)

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