Fig. 1
From: Predicting existing targets for new drugs base on strategies for missing interactions
Spy strategy to identify reliable non-DTI. Positives (P), unlabeled instances (U), spy instances(S) taken from positives, and reliable negatives (RN) identified among unlabeled instances, are rendered with red bars, gray bars, red frames and blue bars respectively. The traditional classifier is trained by positives and unlabeled instances (treated as negatives directly). The Spy-based classifier is built by injecting S into U and investigating the behavior of S to identify RN. The final classifier is trained with positives and RN