Fig. 2
From: Predicting existing targets for new drugs base on strategies for missing interactions
Super-target strategy to gather more similar DTIs (positives). (a) DTI graph and its adjacent matrix. (b) The groups of similar targets and their corresponding columns in the adjacent matrix. (c) Drug-supertarget interaction graph and its adjacent matrix. The graph (left) and the adjacency matrices (right) are different ways to represent the interactions between four drugs and five targets. The drugs (circles), targets (squares) and super-targets (dashed rectangles) are labeled by the names starting with “d”, “t” and “st” respectively. Similar targets are in the same color. The adjacency matrix between the drugs and super-targets (bottom right) is obtained from the original DTI matrix (top right) by performing the union operation on the columns corresponding to targets belonging in the same super-target