Set 1 | Physicochemical descriptors | Set 3 | Composite physicochemical descriptors |
 |  Volume |  |  Volume/P(helix) |
 |  Log(solubility) |  |  Volume/P(sheet) |
 |  Hydrophobicity |  |  Volume/log(solubility) |
 |  Isoelectric point |  |  Log(solubility) x Flexibility |
 |  P(helix) |  |  Steric hindrance x Flexibility |
 |  Steric hindrance |  |  P(helix) + P(sheet) |
 |  P(sheet) |  |  log(solubility) x Hydrophobicity |
 |  Flexibility |  |  Hydrophobicity x Flexibility |
Set 2 | Metabolic descriptors |  |  Volume/(P(helix) + P(sheet)) |
 |  In vivo decay time |  |  Steric hindrance/P(helix) |
 |  Cost for synthesis |  |  Isoelectric point/P(sheet) |
 |  |  |  Volume x Isoelectric Point |
 |  |  |  Isoelectric point/P(helix) |
 |  |  |  P(helix)/P(sheet) |
 |  |  |  Steric hindrance/P(sheet) |
 |  |  |  P(helix) x Flexibility |
 |  | Set 4 | Discrete descriptors |
 |  |  |  Number of Oxygen atoms in side chain |
 |  |  |  Number of Nitrogen atoms in side chain |
 |  |  |  Number of Sulfur atoms in side chain |
 |  |  |  Number of H-bond donors and acceptors in side chain |