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Fig. 10 | BMC Bioinformatics

Fig. 10

From: A model of the spatial tumour heterogeneity in colorectal adenocarcinoma tissue

Fig. 10

Examples of synthesised images demonstrating the effects of different parameter values. Figures (a)–(c) show examples of simulated images of healthy colon tissue. The images are 1000×1000 pixels, at magnification (a, b) 40 × and (c) 20 ×. In figure (b) the overlap L max =0.2 and the cellularity ν s =ν e =1. All other figures have L max =0.6 and the cellularity ν s =ν e =1. Figures (d)–(f) show various differentiation grades. The images are 1000×1000 pixels, at magnification 20 ×. The figures show (d) well differentiated, (e) moderately differentiated, and (f) poorly differentiated cancers. Figures (a) and (b) were generated using the stain vector proposed by [27], whereas the rest of the Figures were generated using the stain matrix in Eq. 17

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