Fig. 1
From: Reference-free deconvolution of DNA methylation data and mediation by cell composition effects
Overview of proposed Methods. If associations between DNA methylation data Y and phenotypic metadata X factor through the decomposition Y = MΩ T, and the data in M serve to distinguish cell types by their associations with relevant annotation data, then associations between X and Y are explained in whole or in part by differences in the distribution of constituent cell types. Numbers indicate steps in analysis: (1) deconvolution; (2) determining discriminating loci; (3) gene-set analysis; (4) analysis of associations with phenotype