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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Profiling networks of distinct immune-cells in tumors

Fig. 1

An integrated bioinformatics workflow to capture DIST signatures: a Using Medline gene indexes and the gene association to general immune-cell keywords, GIT associated genes are extracted in an automated manner from the literature. b Accessing large public resources for DIST transcriptome repositories, DIST enriched genes are determined and used to build DIST-specific protein networks via the integration of the human interactome. c Similarity matrices are built using the DIST-specific networks based on similarity in protein interaction partners. The DIST-specific similarity matrices are then subject to affinity propagation, whereby the resulting clusters are used to identify DIST marker genes

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