Fig. 4

Patient networks (depicting averages over patient groups) of altered immune network landscapes in perturbed MAPK signaling of metastatic melanomas. Nodes are labeled as a GIT which corresponds to at least one DIST. Edges are included in the networks only if the log2 ratio of the DIST pair is greater than 0.5 and their exists a cytokine to cytokine-receptor relationships between the DIST pairs. Both networks in the left and right panels are identical, except for the sides of the nodes, which are scaled proportional to the average GIT immune-cell score for all the patients in the group. a As in pre-treated chemotherapy metastatic melanoma patients, there is high CD8 and Th1 immune-cell scores, accompanied by immunosuppressive cells. Possibly indicating a tumor-killing potential pre-therapy with co-occurring immune suppressive barriers. b The average size of the immune-cell scores has been visibly altered by the chemotherapy, as visible between pre-treated and resistant patients (naturally, also their respective ratios with each other in the networks). This was most notable for Th1 and CD8+ T cells between both networks