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Table 6 Type I error rate simulations for two SNPs with MAFs of (0.2 and 0.2; 0.3 and 0.15) and with different numbers of DSPs at the significant levels of 0.05 and 0.01

From: GCORE-sib: An efficient gene-gene interaction tool for genome-wide association studies based on discordant sib pairs

MAF/number of DSPs

α = 0.05

α = 0.01

MAF 0.2, 0.2

250 DSPs

0.0486

0.0092

500 DSPs

0.0494

0.0086

1000 DSPs

0.0500

0.0106

MAF 0.3, 0.15

250 DSPs

0.0502

0.0114

500 DSPs

0.0484

0.0106

1000 DSPs

0.0510

0.0124